Phenylacetone Synthesis Methamphetamine

 

Phenyl-2-propanone (Compound 1), commonly referred to as P2P, is an intermediate precursor in the manufacture of d,l-amphetamine, d,l-methamphetamine, and other similar phenethylamines (Fig. 1). Its prominent use in the illicit manufacture of amphetamine and methamphetamine has resulted in the United States Government controlling the commercial sale of P2P in 1980 (21 CFR 1308.12, Schedule II, 8501).

The scheduling of P2P has not, however, precluded the illicit manufacture of amphetamine or methamphetamine by this route. Indeed, the reductive amination of P2P remains a popular synthetic route for clandestine drug chemists. The variety of synthetic reductive routes in the literature which utilize P2P to synthesize amphetamine or methamphetamine has been the subject of a recent review¹.

The control of P2P has seriously restricted its commercial availability to clandestine chemists. However, many clandestine chemists have modified their manufacturing schemes by synthesizing their own P2P. Thus, P2P is now illicitly produced from yet other precursors and has its own underground market value. The current 1991 values of P2P are reported to be between $1800 and $2000 per litre.

Many of the syntheses of P2P described in the literature are outlined in Table 1^2-41. Although all of these routes are viable, the clandestine manufacture of P2P has centered on Routes 1A, 1B, 2, and 8A. Routes 1A and 1Bhave dominated in the western and northwestern parts of the United States and are the subject of this paper. It is the authors' objective in this investigation to establish criteria by which these two synthetic routes can be distinguished on the basis of the presence or absence of specific by-products. Such information is necessary for the forensic chemist and the investigator to establish consistencies between precursors, notes, waste products, and the finished product recovered from a clandestine laboratory site; to substantiate informant statements concerning a clandestine laboratory operation; and to predict possible safety hazards prior to the seizure of a clandestine laboratory.

 

Fig. 1

 

R₁, R₂ = H - Amphetamine R₁ = H, R₂ = CH₃ - Methamphetamine 
R₁, R₂ = CH₃ - Dimethylamphetamine

 

Oldal: Phenylacetone Synthesis Methamphetamine
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